Genetic diversity of the African malaria vector Anopheles gambiae
The Anopheles gambiae 1000 Genomes Consortium (including Christina M. Bergey)
Miles et al (2017) Nature. 552: 96–100. doi: 10.1038/nature24995
PDF available upon request. PDF of preprint available from bioRxiv.
Abstract: The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
Select Tweets:
#ThrowBackThursday: Variation data from the An. gambiae Ag1000g consortium AR3 data release is now available via the @VectorBase genome browser – 50 million variant calls, 765 individual mosquitoes, 15 different African locations from this paper: https://t.co/R3ieVjBZMq
— VectorBase (@VectorBase) September 13, 2018
Ag1000G is finally in print! Results from phase 1, with new analyses of gene drive, migration and population size. Thanks to all consortium members https://t.co/WPnyhg659z and everyone behind the scenes @malariagenomics resource center and @sangerinstitute operations. https://t.co/OKsaqaChJt
— Alistair Miles (@alimanfoo) November 29, 2017
Largest genetic study of #mosquitoes shows rapid #evolution of insecticide resistance genes. Researchers also discovered many previously unknown insecticide resistant #genetic variants that are #emerging all over #Africa and rapidly spreading. https://t.co/WEM4pq4d7x pic.twitter.com/7qkmFnH1SF
— David Markman (@david_markman) December 14, 2017
To study #insecticide resistance among #malaria-carrying #mosquitoes in Africa, #NIAID-funded researchers sequenced the genomes of 765 mosquitoes. Read more about the first phase of this @malariagenomics project: https://t.co/XyPR8lqLxE pic.twitter.com/RrI8fzLM2z
— NIAID News (@NIAIDNews) November 30, 2017
The genetic diversity of the hosts responsible for the majority of malaria transmission in Africa, Anopheles gambiae and Anopheles coluzzii mosquitoes, is presented in a study this week https://t.co/Ve0iwUVZCH pic.twitter.com/XyMSQwyPPi
— nature (@nature) November 30, 2017
Hot off the presses! Our latest publication in #Nature describes the wondrous genetic diversity of the African malaria vector https://t.co/Yhd9GcmS35
Learn more about this true consortial effort https://t.co/izBvFYBaI0 @sangerinstitute @LSTMnews @bdi_oxford @NDMOxford #ag1000g
— MalariaGEN (@malariagenomics) November 30, 2017
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